Difficulties arise in attempting to understand the mechanisms of antiarrhythmic drug action for several reasons. 在企图了解抗心律失常药物作用的机制中产生某些困难是有一些原因的。
An antiarrhythmic drug ( trade name Mexitil) used to treat ventricular arrhythmias. 用来治疗心室膨胀、心律不齐的抗心律不齐的药物(商标是麦可息提)。
Since CaM kinase is uniquely positioned to affect Ca 2+ sensitive ionic currents and resultant arrhythmias, CaM kinase may also be an effective antiarrhythmic drug target. 由于钙调蛋白激酶能影响各种钙敏感离子电流及导致心律失常,有可能是一种有效的抗心律失常药物作用靶位。
Electrophysiological effects of antiarrhythmic drug UK-68798 on different AV nodal cells in rabbit heart 抗心律失常药UK-68798对家兔心脏房室结区不同细胞的电生理作用
Objective To search the new targets of antiarrhythmic drug. 目的寻找抗心律失常药物作用的新靶点。
Effect of new antiarrhythmic drug CHANGROLIN on the threshold of fibrillation elicited electrically in rabbits and dogs 抗心律失常新药常咯啉对电刺激引起的室颤阈值的影响
Advance in search for clinical pharmacology on antiarrhythmic drug of amiodarone 抗心律失常药胺碘酮临床药理学研究进展
Objective: In order to select suitable antiarrhythmic agents ( AAA), the effects of AAA on ventricular late potentials ( VLP) were studied by acute drug trial; 目的:通过急性药物试验,研究抗心律失常药物对心室晚电位(VLP)的影响,为选用合适的抗心律失常药物。
Dofetilide is a new class ⅲ antiarrhythmic drug. 多非利特是一个新型的第3类抗心律失常药物。
Based on the gate-related receptor hypothesis, an analysis on kinetics of AN-132, a new antiarrhythmic agent, blockade of cardiac sodium channels and the gate-related receptor which be bound by the drug was performed by computer simulation. 根据闸门相关受体假说,应用计算机模拟,分析了新抗心律失常药AN-132阻滞心肌钠通道的动力学特点,及其作用的闸门相关受体。
Clinical significances of serial electropharmacologic study in regard to screen out effective antiarrhythmic drug on reentrant supraventricular tachycardia 系列电药理研究筛选有效抗折返性室上性心动过速药物的临床意义
Dofetilide, a new class ⅲ antiarrhythmic drug, takes effect through blocking I_ ( kr) and prolonging action potential duration ( QT interval). 多非力特是一种新型Ⅲ类抗心律失常药物,通过抑制钾电流(Ikr)增加动作电位持续时间(QT间期)而发挥效应。
Based on published papers, this article has reviewed the metabolism of antiarrhythmic drugs, emphasizing on the affecting factors including genetics, sex and drug interaction. 本文综述了抗心律失常药物代谢的研究进展,并详细报道遗传因素、性别因素及药物间相互作用等对抗心律失常药物代谢的影响及其临床意义。
Conclusion miRNA is a new target of antiarrhythmic drug since it is involved in the modulation of continuous AF. 结论miRNA参与了持续性AF的调节作用,提示miRNA是抗心律失常药物作用的新靶点。
Dofetilide: ANew Class ⅲ antiarrhythmic Drug 多非力特:一种新型的纯Ⅲ类抗心律失常药物
They were assigned to antiarrhythmic therapy group ( Group A), ICD group ( Group B) and low frequency ventricular tachycardia with drug therapy group ( Group C), according to the electrophysiological results of programmatic ventricular stimulation. 根据电生理心室程序刺激结果将患者分为药物治疗组(A组)、ICD组(B组)和慢频率室速药物治疗组(C组)。
The functions of class I antiarrhythmic drug changrolin are to affect Na+ transportation and to correct electric physiology disorders. 第Ⅰ类抗心律失常药Changrolin是影响Na+转运、纠正电生理紊乱而发挥作用。在Changrolin结构基础上,进行系统地结构改造和修饰,形成一系列抗心律失常药。
Proarrhythmia of antiarrhythmic drug assessed by QT dispersion in patients with congestive 用QT间期离散度监测充血性心力衰竭患者使用抗心律失常药物致心律失常的研究
Effective prevention has the potential to decrease the AF-related morbidity and mortality, but antiarrhythmic drug therapy has been disappointing because of inadequate efficacy and proarrhythmic risks. 有效的预防措施可以减少房颤相关的发病率和死亡率,但是抗心律失常药物往往疗效有限且具有致心律失常作用。